How adding structure to your workouts may slow biological aging

A new study suggests that while everyday movement like walking offers clear health benefits, structured exercise routines may be even more powerful in slowing down the body’s internal clock.
Researchers from Tohoku University reviewed existing evidence on “epigenetic aging,” which looks at chemical changes on DNA that reveal how quickly our cells are really aging. Their findings highlight that planned and repetitive workouts, such as aerobic exercise and resistance training, may have stronger effects on reducing biological age than general daily activity.
The review pulled together both animal and human studies. In mice, structured endurance and resistance training helped reverse age-related molecular changes in muscle tissue. In humans, structured exercise showed measurable reductions in biological age.
What exercise habits work best for anti-aging?
The theme at large is that structured exercise seems to deliver the strongest anti-aging effects. That means planned routines that are repetitive and goal-driven, such as regular cardio sessions, weight training, or ideally, a combination of the two.
Still, take this with a pinch of salt. The review included mouse studies as well as human trials, and unless you are planning to train on a hamster wheel, you probably want to temper your expectations.
Also, while the study suggests walking and other casual activities may not have a strong impact on epigenetic aging, that does not mean it should be written off. Walking is one of the most versatile forms of exercise, and you can make it structured if you want to.
The Japanese walking method, for example, alternates between three minutes of fast walking and three minutes of slower walking for a total of 30 minutes. My editor has even designed her own 3-4-5 walking workout, where you switch speeds every few minutes to add a burst of HIIT to your steps. Basically, it's possible to make more "casual activities" more purposeful and challenging without needing gym equipment.
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How to incorporate the findings into your routine
If you are already walking every day, keep it up. It is an excellent base. But if you want to lean into the anti-aging benefits highlighted in this study, consider layering in more structured exercise. That could mean two or three cardio sessions per week, such as cycling, swimming or running, along with a couple of strength workouts that challenge your major muscle groups.
The most important step is to find activities you enjoy and can stick with. If lifting weights feels daunting, a selection of the best resistance bands or bodyweight circuits can achieve similar results. If you don't enjoy running, mix brisk walking with speed intervals instead. You may not be able to stop the calendar from ticking forward, but by adding structure and consistency to your exercise, you can help your body feel and function younger for longer.
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Jessica has been a fitness writer at Tom’s Guide since 2023, bringing three years of experience writing about health, fitness, and the great outdoors. Her passion for exercise began during her childhood, where she spent weekends hiking and competing in local athletics club events. After earning a master’s degree in journalism from Cardiff University, Jessica found the perfect way to combine her love of storytelling and fitness into a career.
Jessica is passionate about testing fitness gear and tech, using her reviews to help readers make informed buying decisions. She ran her first marathon in April 2024, finishing it in 3 hours and 48 minutes. Through her training, she’s developed a deep understanding of what it takes to grow as a runner, from effective workouts and recovery techniques to selecting the right gear for every challenge.
When she’s not at her desk, Jessica enjoys spending time in the kitchen crafting new recipes, braving cold water swims and hiking.
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