It will (probably), BUT it will be not that noticeable IMO. Moreover if you run it at 3.8Ghz+.
Now, Crossfire depends also on the PCIe lanes. If you'r thinking about 790 or 890 MoBos you'll be fine in that aspect. CPU wise, I really don't know if it will be THAT horrendous; my intuition says it won't, but don't have data (on that CPU) to back up that claim 8(
Cheers!