do you mean use the 3.5mm cable, strip it and put the two wires into the rear of two home theater or hifi speakers?
yeah, unless they are some very small speakers (or are self powered) that would be a big no.
to use a pair of speakers meant for home audio typically you would need an amplifier. some are as cheap as $20 and you could use a 3.5mm cable to connect to your pc.